2021–22 Pakistan Women's One Day Cup
| Dates | 9 – 21 September 2021 |
|---|---|
| Administrator(s) | Pakistan Cricket Board |
| Cricket format | 50 over |
| Tournament format(s) | Round-robin and final |
| Champions | PCB Challengers (1st title) |
| Participants | 4 |
| Matches | 14 |
| Player of the series | Aliya Riaz (Dynamites) Nida Dar (Blasters) |
| Most runs | Aliya Riaz (364) |
| Most wickets | Nida Dar (14) Anoosha Nazir (14) Saba Nazir (14) |
The 2021–22 Pakistan Women's One Day Cup was a 50-over women's cricket competition that took place in Pakistan in September 2021. It was the first edition of the competition under its new name, and saw the addition of a new team, PCB Strikers. All matches took place in Karachi, at the National Stadium and the Pakistan Cricket Board Academy Ground.
PCB Challengers beat defending champions PCB Blasters in the final by 68 runs to claim their first one-day title. PCB Strikers beat PCB Dynamites in the third place play-off.