2021–22 Professional U23 Development League

Premier League 2
Season	2021-22
Champions	Manchester City U23s (2nd Title); Division 2; Fulham U23s (1st Title)
Promoted	Fulham U23s; Wolverhampton Wanderers U23s
Relegated	Leeds United U23s; Derby County U23s
Matches played	395; (392 RS, 3 PO)
Goals scored	1,289 (3.26 per match); (1,283 RS, 6 PO)
Top goalscorer	James McAtee Manchester City U23s, Jesurun Rak-Sakyi Crystal Palace U23s (18 goals)
Biggest home win	Nottingham Forest U23s 7–0 Reading U23s; (21 February 2022); Manchester City U23s 7–0 Everton U23s; (29 April 2022)
Biggest away win	Stoke City U23s 0–8 Aston Villa U23s; (27 September 2021)
Highest scoring	Leeds United U23s 4–4 Blackburn Rovers U23s; (24 September 2021); Stoke City U23s 0–8 Aston Villa U23s; (27 September 2021); Arsenal U23s 3–5 Derby County U23s; (26 November 2021); Blackburn Rovers U23s 3–5 Manchester City U23s; (9 January 2022); Liverpool U23s 7–1 Tottenham Hotspur U23s; (12 March 2022); Fulham U23s 5–3 Burnley U23s; (1 May 2022)
Longest winning run	6 Matches Manchester City U23s
Longest unbeaten run	12 Matches Manchester City U23s
Longest winless run	13 Matches Derby County U23s
Longest losing run	6 Matches Derby County U23s
Highest attendance	21,321 Leeds United U23s 1–3 Manchester City U23s; (22 April 2022) League Record
Lowest attendance	31 Crystal Palace U23s 1–1 Arsenal U23s; (19 March 2022)
	← 2020–21 2022–23 →

The 2021–22 Professional U23 Development League was the tenth season of the Professional Development League system.

Nottingham Forest U23s and Birmingham City U23s both gained category one status. Manchester City U23s were the defending champions and successfully defend the title. Leeds United U23s and Crystal Palace U23s were both promoted and Southampton U23s were relegated.