2021–22 Serie C
| Season | 2021–22 |
|---|---|
| Dates | Regular season: 28 August 2021 – 24 April 2022 Play-offs and play-outs: 1 May 2022 – 12 June 2022 |
| Promoted | Südtirol Modena Bari Palermo (via play-off) |
| Relegated | Seregno Giana Erminio Legnago Teramo (excluded) Pistoiese Grosseto Campobasso (excluded) Paganese Vibonese Catania (excluded) |
| Matches played | 1,102 |
| Goals scored | 2,583 (2.34 per match) |
| Top goalscorer | Matteo Brunori (25+4 goals) |
| Biggest home win | Feralpisalò 6–0 Pergolettese (27 November 2021) Cesena 6–0 Carrarese (14 April 2022) |
| Biggest away win | Pontedera 0–5 Ancona-Matelica (22 January 2022) |
| Highest scoring | Paganese 4–4 ACR Messina (28 August 2021) Campobasso 4–4 Catania (6 November 2021) Picerno 5–3 Paganese (11 December 2021) Virtus Francavilla 4–4 Campobasso (3 April 2022) Foggia 2–6 Catanzaro (11 April 2022) |
| Longest winning run | Modena (9–20, 23–24) (14 matches) |
| Longest unbeaten run | Südtirol (1–28) (28 matches) |
| Longest winless run | Giana Erminio (7–20, 23) (15 matches) |
| Longest losing run | Siena (15–20) (6 matches) |
| Highest attendance | 35,037 Palermo 1–0 Feralpisalò (29 May 2022) |
| Lowest attendance | 80 Juventus U23 0–1 Giana Erminio (29 September 2021) |
| Total attendance | 2,027,508 |
| Average attendance | 1,711 |
← 2020–21 2022–23 → | |
The 2021–22 Serie C was the 63rd season of the Serie C, the third tier of the Italian football league system, organized by the Lega Pro.