2021–22 Thai League 3 Northeastern Region
| Season | 2021–22 | 
|---|---|
| Dates | 4 September 2021 – 26 February 2022 | 
| Champions | Muang Loei United | 
| Relegated | Mashare Chaiyaphum | 
| T3 National Championship | Muang Loei United Sisaket  | 
| Matches played | 156 | 
| Goals scored | 474 (3.04 per match) | 
| Top goalscorer |  Watthanapon Chinthong (19 goals; Surin City)  | 
| Best goalkeeper |  Putawan Prangthong (11 clean sheets; Nakhon Ratchasima United)  | 
| Biggest home win | 8 goals difference Surin City 8–0 Mashare Chaiyaphum (5 February 2022)  | 
| Biggest away win | 7 goals difference Mashare Chaiyaphum 0–7 Muang Loei United (21 November 2021)  | 
| Highest scoring | 10 goals Mashare Chaiyaphum 2–8 Ubon Kruanapat (11 September 2021)  | 
| Longest winning run | 8 matches Sisaket  | 
| Longest unbeaten run | 14 matches Nakhon Ratchasima United  | 
| Longest winless run | 24 matches Mashare Chaiyaphum  | 
| Longest losing run | 11 matches Mashare Chaiyaphum  | 
| Highest attendance | 1,035 Sisaket 2–0 Mahasarakham (20 February 2022)  | 
| Lowest attendance | 0 | 
| Total attendance | 17,537 | 
| Average attendance | 177 | 
← 2020–21  2022–23 →   | |
The 2021–22 Thai League 3 Northeastern region is a region in the regional stage of the 2021–22 Thai League 3. The tournament was sponsored by Blue Dragon Lottery Online, and known as the Blue Dragon League for sponsorship purposes. A total of 13 teams located in Northeastern of Thailand will compete in the league of the Northeastern region.