2021–22 Thai League 3 Southern Region
| Season | 2021–22 | 
|---|---|
| Dates | 4 September 2021 – 27 February 2022 | 
| Champions | Krabi | 
| Relegated | Satun United Surat Thani  | 
| T3 National Championship | Krabi Nakhon Si United  | 
| Matches played | 156 | 
| Goals scored | 382 (2.45 per match) | 
| Top goalscorer |  Mairon Natan Pereira Maciel Oliveira (14 goals; Songkhla)  | 
| Best goalkeeper |  Wuttichai Panbut (16 clean sheets; Krabi)  | 
| Biggest home win | 9 goals difference Songkhla 10–1 Surat Thani (18 December 2021)  | 
| Biggest away win | 6 goals difference Surat Thani 0–6 Krabi (16 February 2022)  | 
| Highest scoring | 11 goals Songkhla 10–1 Surat Thani (18 December 2021)  | 
| Longest winning run | 6 matches Krabi Nakhon Si United Nara United  | 
| Longest unbeaten run | 14 matches Songkhla  | 
| Longest winless run | 24 matches Surat Thani  | 
| Longest losing run | 13 matches Surat Thani  | 
| Highest attendance | 1,851 Songkhla 2–0 Nara United (13 February 2022)  | 
| Lowest attendance | 0 | 
| Total attendance | 35,012 | 
| Average attendance | 381 | 
← 2020–21  2022–23 →   | |
The 2021–22 Thai League 3 Southern region is a region in the regional stage of the 2021–22 Thai League 3. The tournament was sponsored by Blue Dragon Lottery Online, and known as the Blue Dragon League for sponsorship purposes. A total of 13 teams located in Southern of Thailand will compete in the league of the Southern region.