2021 Abierto Zapopan – Singles
| Singles | |
|---|---|
| 2021 Abierto Zapopan | |
| Champion | Sara Sorribes Tormo |
| Runner-up | Eugenie Bouchard |
| Score | 6–2, 7–5 |
| Draw | 32 (6 Q / 3 WC) |
| Seeds | 8 |
Veronika Kudermetova was the defending champion from 2019, when the tournament was last held as a WTA 125K series event, but she chose to compete in Dubai instead.
Sara Sorribes Tormo won her first WTA Tour singles title, defeating Eugenie Bouchard in the final, 6–2, 7–5.