2021 Dubai Tennis Championships – Men's singles
| Men's singles | |
|---|---|
| 2021 Dubai Tennis Championships | |
| Champion | Aslan Karatsev | 
| Runner-up | Lloyd Harris | 
| Score | 6–3, 6–2 | 
| Draw | 48 (6 Q / 4 WC ) | 
| Seeds | 16 | 
Aslan Karatsev defeated Lloyd Harris in the final, 6–3, 6–2 to win the men's singles tennis title at the 2021 Dubai Tennis Championships. It was his first ATP Tour singles title. Karatsev was the second wildcard in the tournament's history to win the men's singles title.
Novak Djokovic was the reigning champion, but chose not to participate this year.