2021 Engie Open de Biarritz – Singles

Singles
2021 Engie Open de Biarritz
Champion Francesca Jones
Runner-up Oksana Selekhmeteva
Score6–4, 7–6(7–4)

The 2021 Engie Open de Biarritz – Singles was the singles event in the 18th edition of the Engie Open de Biarritz, a professional women's tennis tournament played on outdoor clay courts.

Viktoriya Tomova was the defending champion, having won the previous edition in 2019, however she chose to compete in Budapest instead.

Francesca Jones won the title, defeating Oksana Selekhmeteva in the final, 6–4, 7–6(7–4).