2021 French Open – Wheelchair women's singles

Wheelchair women's singles
2021 French Open
Champion Diede de Groot
Runner-up Yui Kamiji
Score6–4, 6–3

Diede de Groot defeated the defending champion Yui Kamiji in the final, 6–4, 6–3 to win the women's singles wheelchair tennis title at the 2021 French Open. It was the second step in an eventual Super Slam for de Groot, and she completed the double career Grand Slam with the win.