2021 French Open – Women's singles

Barbora Krejčíková defeated Anastasia Pavlyuchenkova in the final, 6–1, 2–6, 6–4 to win the women's singles tennis title at the 2021 French Open. It was her first major singles title. Krejčíková saved a match point en route to the title, in the semifinals against Maria Sakkari. Krejčíková and Pavlyuchenkova were the combined lowest-ranked major finalists (world Nos. 33 and 32, respectively) since the introduction of the computer rankings in 1975 (a feat surpassed just three months later at the US Open).

Krejčíková was the first Czech to win the title since Hana Mandlíková in 1981. She was also the first player to win both the singles and doubles titles at the same major since Serena Williams at the 2016 Wimbledon Championships, and the first to do so at the French Open since Mary Pierce in 2000. Pavlyuchenkova reached her first major final after participating in 52 major main draws, breaking the record previously set by Flavia Pennetta in the 2015 US Open.

Iga Świątek was the defending champion, but lost to Sakkari in the quarterfinals. Świątek's loss marked the 14th consecutive year where the reigning French Open champion failed to defend their title, with Justine Henin being the last woman to do so in 2007 (Świątek would end this stretch herself two years later). It ensured the sixth consecutive French Open to feature a first-time major champion. Świątek's loss also ensured that this was the first French Open and the third major in the Open Era to feature all first-time major semifinalists, and it was the first major in the Open Era in which six players made their major quarterfinal debuts.

Ashleigh Barty and Naomi Osaka were in contention for the world No. 1 singles ranking. Barty retained the top ranking after Osaka withdrew from the second round.

Serena Williams was the oldest woman in the Open Era to reach the fourth round; this was also the three-time champion's final French Open appearance before retiring from professional tennis the following year. Sakkari and Tamara Zidanšek became the first Greek woman and Slovenian player to reach the singles quarterfinals and semifinals of a major, respectively. Coco Gauff was the youngest player to reach a major quarterfinal since Nicole Vaidišová at the 2006 French Open.