2021 Hamburg European Open – Women's singles

Women's singles
2021 Hamburg European Open
Champion Elena-Gabriela Ruse
Runner-up Andrea Petkovic
Score7–6(8–6), 6–4

Kim Clijsters was the defending champion, having won the previous edition in 2002, but chose not to participate.

Elena-Gabriela Ruse won her maiden WTA Tour singles title as a qualifier, defeating Andrea Petkovic in the final, 7–6(8–6), 6–4.

This tournament marked Dayana Yastremska's return to professional tennis, after her suspension for testing positive for a prohibited substance was lifted by the ITF.

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