2021 Internazionali Femminili di Palermo – Singles
| Singles | |
|---|---|
| 2021 Internazionali Femminili di Palermo | |
| Champion | Danielle Collins |
| Runner-up | Elena-Gabriela Ruse |
| Score | 6–4, 6–2 |
| Draw | 32 |
| Seeds | 8 |
Fiona Ferro was the defending champion, but she chose not to participate, as she was competing at the Summer Olympics.
Top seed Danielle Collins won her maiden WTA Tour singles title, defeating Elena-Gabriela Ruse in the final, 6–4, 6–2. Collins did not drop a set during the tournament.