2021 Ladies Open Lausanne – Singles
| Singles | |
|---|---|
| 2021 Ladies Open Lausanne | |
| Champion | Tamara Zidanšek | 
| Runner-up | Clara Burel | 
| Score | 4–6, 7–6(7–5), 6–1 | 
Fiona Ferro was the defending champion from 2019, when the event was last held, but lost to Clara Burel in the quarterfinals.
Tamara Zidanšek won her maiden WTA Tour singles title, defeating Burel in the final, 4–6, 7–6(7–5), 6–1.