2021 Los Cabos Open – Singles
| Singles | |
|---|---|
| 2021 Los Cabos Open | |
| Champion | Cameron Norrie |
| Runner-up | Brandon Nakashima |
| Score | 6–2, 6–2 |
| Draw | 28 (4 Q / 3 WC ) |
| Seeds | 8 |
Diego Schwartzman was the reigning champion from when the tournament was last held in 2019, but chose to compete at the Summer Olympics instead.
Cameron Norrie won his maiden ATP Tour title, defeating Brandon Nakashima in the final, 6–2, 6–2.