2021 Monterrey Open – Singles
| Singles | |
|---|---|
| 2021 Monterrey Open | |
| Champion | Leylah Fernandez | 
| Runner-up | Viktorija Golubic | 
| Score | 6–1, 6–4 | 
Leylah Fernandez defeated Viktorija Golubic in the final, 6–1, 6–4 to win the singles tennis title at the 2021 Monterrey Open. Fernandez did not drop a set en route to her first WTA Tour singles title.
Elina Svitolina was the reigning champion, but decided not to participate.