2021 National Bank Open – Women's singles

Women's singles
2021 National Bank Open
Champion Camila Giorgi
Runner-up Karolína Plíšková
Score6–3, 7–5
Draw56 (8 Q / 5 WC )
Seeds16

Camila Giorgi defeated Karolína Plíšková in the final, 6–3, 7–5 to win the women's singles tennis title at the 2021 Canadian Open. It was her third career WTA Tour title, her first at the WTA 1000 level, and her first since Linz in 2018.

Bianca Andreescu was the defending champion from when the event was last held in 2019, but lost in the third round to Ons Jabeur.