2021 National Premier Soccer League season

National Premier Soccer League
Season	2021
Dates	May 1 – July 17; (regular season); July 14 – August 7; (playoffs)
Champions	Denton Diablos FC (1st Title)
Regular season title	Minneapolis City SC (1st Title)
2022 Hank Steinbrecher Cup qualifier	Denton Diablos FC
2022 U.S. Open Cup qualifiers	Cleveland SC; Denton Diablos FC; Georgia Revolution FC; Hartford City FC; Las Vegas Legends; Miami United FC; Minneapolis City SC; FC Motown; Southern States Soccer Club; Tulsa Athletic
Matches played	403
Goals scored	1,597 (3.96 per match)
Top goalscorer	16 Goals; Sidney Warden (Duluth)
Biggest home win	G. Storm 14–0 Louisville; (June 26)
Biggest away win	Dallas City 1–9 OKC; (June 12)
Highest scoring	G. Storm 14–0 Louisville; (14 goals, June 26)
Longest winning run	10 matches; Minneapolis City SC; (May 8 – June 30)
Longest unbeaten run	10 matches; Minneapolis City SC; (May 8 – June 30); Atlantic City FC; (May 8 – July 7); Cleveland SC; (May 16 – July 17); Demize NPSL; (May 28 – July 10); Baltimore Christos; (May 29 – July 10)
Longest winless run	12 matches; La Crosse Aris FC; (May 15 – July 17)
Longest losing run	10 matches; Greater Lowell; (May 8 – July 10); Storm FC; (May 8 – July 3); Hershey FC; (May 15 – June 30); Dallas City FC; (May 23 – July 10)
	← 2020; (Cancelled) 2022 → All statistics correct as of July 17, 2021.

The 2021 National Premier Soccer League season was the 19th season of the National Premier Soccer League and part of the 109th season of FIFA-sanctioned soccer in the United States. The 2020 season was cancelled after five weeks of play due to the COVID-19 pandemic. Miami FC, the defending league champions from 2019, left in the previous off-season and joined the National Independent Soccer Association and later the USL Championship.

The regular season started on May 1 and concluded on July 17. In total, 76 teams participated this season with a further 14 playing in conferences that decided not to participate in the summer season.