2021 Volvo Car Open – Singles
| Singles | |
|---|---|
| 2021 Volvo Car Open | |
| Champion | Veronika Kudermetova |
| Runner-up | Danka Kovinić |
| Score | 6–4, 6–2 |
| Draw | 56 |
| Seeds | 16 |
Veronika Kudermetova defeated Danka Kovinić in the final, 6–4, 6–2, to win the singles tennis title at the 2021 Charleston Open. Kudermetova did not drop a set en route to her first career Women's Tennis Association (WTA) singles title.
Madison Keys was the defending champion, but she lost in the second round to Sloane Stephens in a rematch of the previous tournament's quarterfinal. As all losing quarterfinalists were previous WTA title holders, all four semifinalists were in contention to become a maiden WTA champion.