2021 Western & Southern Open – Women's doubles
| Women's doubles | |
|---|---|
| 2021 Western & Southern Open | |
| Champions | Samantha Stosur Zhang Shuai |
| Runners-up | Gabriela Dabrowski Luisa Stefani |
| Score | 7–5, 6–3 |
| Seeds | 8 |
Květa Peschke and Demi Schuurs were the defending champions, but chose to compete with different partners. Peschke partnered Ellen Perez, and Schuurs partnered Nicole Melichar. Both teams lost to Samantha Stosur and Zhang Shuai; Perez and Peschke did so in the second round, whilst Melichar and Schuurs lost in the quarterfinals.
Stosur and Zhang went on to win the title, defeating Gabriela Dabrowski and Luisa Stefani in the final, 7–5, 6–3.