2021 Wimbledon Championships – Men's singles

Two-time defending champion Novak Djokovic defeated Matteo Berrettini in the final, 6–7^(4–7), 6–4, 6–4, 6–3 to win the gentlemen's singles tennis title at the 2021 Wimbledon Championships. It was his sixth Wimbledon title and record-equaling 20th major men's singles title overall, tying Roger Federer and Rafael Nadal's all-time record total. Djokovic became the first man to win the Australian Open, French Open and Wimbledon titles in the same calendar year since Rod Laver in 1969, the second to achieve the Surface Slam (winning majors on three different surfaces in a calendar year), after Nadal in 2010, and the fifth in the Open Era to win the Channel Slam (French Open—Wimbledon double).

Djokovic and Daniil Medvedev were in contention for the world No. 1 singles ranking; Djokovic retained the top ranking when Medvedev lost in the fourth round.

This event marked the final professional singles appearance of 20-time major champion, eight-time Wimbledon champion and former world No. 1 Roger Federer; he lost in the quarterfinals to Hubert Hurkacz. Federer was the oldest man in the Open Era to reach the Wimbledon quarterfinals, and the oldest man to reach a major quarterfinal since Ken Rosewall in December 1977. His fourth-round victory marked 105 match wins at Wimbledon. The 18 quarterfinals and 119 matches he contested at Wimbledon are both tournament records.

Berrettini was the first Italian man to reach a major final since Adriano Panatta at the 1976 French Open and the first to do so at Wimbledon. Zhang Zhizhen was the first Chinese man to qualify for the Wimbledon main draw in the Open Era. Márton Fucsovics was the first Hungarian to reach a men's singles major quarterfinal since Balázs Taróczy at the 1981 French Open, and the first to do so at Wimbledon since József Asbóth in 1948. This was the first time since 2017 that two-time champion Andy Murray participated.

For the first time since 2002, the grass court seeding formula was abandoned and the standard ranking system based on the ATP rankings was permanently adopted, like at the other three majors.