2022 ATP Lyon Open – Singles
| Singles | |
|---|---|
| 2022 ATP Lyon Open | |
| Champion | Cameron Norrie |
| Runner-up | Alex Molčan |
| Score | 6–3, 6–7(3–7), 6–1 |
| Draw | 28 (4 Q / 3 WC ) |
| Seeds | 8 |
Cameron Norrie defeated Alex Molčan in the final, 6–3, 6–7(3–7), 6–1 to win the singles tennis title at the 2022 ATP Lyon Open. Norrie became the first Briton to win a clay court title on the ATP Tour since 2016.
Stefanos Tsitsipas was the defending champion, but chose not to participate.