2022 Abierto Zapopan – Singles
| Singles | |
|---|---|
| 2022 Abierto Zapopan | |
| Champion | Sloane Stephens |
| Runner-up | Marie Bouzková |
| Score | 7–5, 1–6, 6–2 |
| Draw | 32 |
| Seeds | 8 |
Sloane Stephens defeated Marie Bouzková in the final, 7–5, 1–6, 6–2, to win the singles title at the 2022 Abierto Zapopan. It marked the first final and title for Stephens since 2018.
Sara Sorribes Tormo was the defending champion, but she lost in the quarterfinals to Bouzková.