2022 Argentina Open – Singles
| Singles | |
|---|---|
| 2022 Argentina Open | |
| Champion | Casper Ruud |
| Runner-up | Diego Schwartzman |
| Score | 5–7, 6–2, 6–3 |
| Draw | 28 (4 Q / 3 WC ) |
| Seeds | 8 |
Casper Ruud defeated the defending champion Diego Schwartzman in the final, 5–7, 6–2, 6–3 to win the singles title at the 2022 Argentina Open.
Former US Open champion Juan Martín del Potro played the last professional match of his career against Federico Delbonis in the first round, losing 6-1 6-3.