2022 Atlanta Open – Singles
| Singles | |
|---|---|
| 2022 Atlanta Open | |
| Champion | Alex de Minaur |
| Runner-up | Jenson Brooksby |
| Score | 6–3, 6–3 |
| Draw | 28 |
| Seeds | 8 |
Alex de Minaur defeated Jenson Brooksby in the final, 6–3, 6–3 to win the singles title at the 2022 Atlanta Open. It was de Minaur's second Atlanta title, the first being in 2019.
John Isner was the defending champion, but lost in the quarterfinals to Brooksby.