2022 Citi Open – Women's singles

Women's singles
2022 Citi Open
Champion Liudmila Samsonova
Runner-up Kaia Kanepi
Score4–6, 6–3, 6–3

Liudmila Samsonova defeated Kaia Kanepi in the final, 4–6, 6–3, 6–3 to win the women's singles tennis title at the 2022 Washington Open. Kanepi was aiming to win her first title since 2013, and to be the oldest player to win a WTA Tour title since Serena Williams in 2020.

Jessica Pegula was the defending champion from when the event was last held in 2019, but lost in the second round to Daria Saville.