2022 Columbus Challenger – Singles
| Singles | |
|---|---|
| 2022 Columbus Challenger | |
| Champion | Yoshihito Nishioka |
| Runner-up | Dominic Stricker |
| Score | 6–2, 6–4 |
Stefan Kozlov was the defending champion but lost in the second round to Dominic Stricker.
Yoshihito Nishioka won the title after defeating Stricker 6–2, 6–4 in the final.