2022 French Open – Men's singles

Rafael Nadal defeated Casper Ruud in the final, 6–3, 6–3, 6–0 to win the men's singles tennis title at the 2022 French Open. It was his record-extending 14th French Open title and record-extending 22nd and last major title overall. It was also his 92nd and final ATP Tour-level singles title. Nadal was the third man to defeat four top-10 players en route to a major title since the introduction of ATP rankings in 1973 (after Mats Wilander at the 1982 French Open and Roger Federer at the 2017 Australian Open). Ruud was the first Norwegian man to reach a major quarterfinal and beyond (surpassing his father Christian), and the first Scandinavian man to do so since Robin Söderling in 2010.

Novak Djokovic was the defending champion, but lost in the quarterfinals to Nadal. Their quarterfinal match was their record-extending 59th encounter, and their tenth encounter at the French Open, an Open Era record for two players in one tournament.

Djokovic, Daniil Medvedev and Alexander Zverev were in contention for the world No. 1 singles ranking. Following Djokovic's quarterfinal loss and Zverev's semifinal retirement, Djokovic retained the top position at the end of the tournament. One week later, when points from the previous year's tournament were dropped, Medvedev reclaimed the top ranking, while Zverev reached world No. 2, ending the Big Three's streak in the top two spots since 10 November 2003. Additionally, as Federer did not enter the tournament, he fell out of the top 50 in the ATP rankings for the first time since 5 June 2000.

Stefanos Tsitsipas' fourth-round loss guaranteed a first-time French Open finalist from the bottom half of the draw, with Ruud emerging as that finalist. Holger Rune was the first Danish man to reach a major singles quarterfinal in the Open Era. This tournament marked the first time since the 2002 Australian Open that Feliciano López failed to qualify for the main draw of a major, ending his record streak of 79 consecutive major appearances. This marked the final professional appearance of former world No. 5 and 2008 Australian Open runner-up Jo-Wilfried Tsonga, who lost in the first round to Ruud.

This was the first edition of the French Open to feature a tiebreak (10-point) in the fifth set when the match reached 6 games all. Camilo Ugo Carabelli and Aslan Karatsev became the first players to contest this tiebreak in the main draw in their first-round match.