2022 Los Cabos Open – Singles
| Singles | |
|---|---|
| 2022 Los Cabos Open | |
| Champion | Daniil Medvedev |
| Runner-up | Cameron Norrie |
| Score | 7–5, 6–0 |
| Draw | 28 (4 Q / 3 WC ) |
| Seeds | 8 |
Daniil Medvedev defeated the defending champion Cameron Norrie in the final, 7–5, 6–0 to win the singles tennis title. It was his 14th career ATP Tour title, his first of the season, and his first since the 2021 US Open eleven months earlier.