2022 Miami Open – Men's singles

Carlos Alcaraz defeated Casper Ruud in the final, 7–5, 6–4 to win the men's singles tennis title at the 2022 Miami Open. It was his first Masters 1000 title, and he was the first Spaniard to win the title. The victory also made Alcaraz, at 18 years and 333 days old, the youngest men's singles champion in Miami Open history (surpassing Novak Djokovic's record from 2007), and the youngest Masters 1000 champion since Rafael Nadal at the 2005 Monte Carlo Masters. Ruud was the first Norwegian to reach a Masters 1000 final, and the first Scandinavian since Robin Söderling at the 2010 Paris Masters.

Hubert Hurkacz was the defending champion, but lost in the semifinals to Alcaraz.

By reaching the semifinals on his Masters 1000 debut, Francisco Cerúndolo became the first player to achieve the feat since Jerzy Janowicz at the 2012 Paris Masters. Ranked No. 103, Cerúndolo was also the lowest-ranked semifinalist in tournament history.

Novak Djokovic and Daniil Medvedev were in contention for the world No. 1 singles ranking. Djokovic retained the top ranking when Medvedev lost in the quarterfinals to Hurkacz.

At the time, this tournament marked the final professional appearance of former world No. 5 and two-time major finalist Kevin Anderson, who lost in the second round to Juan Manuel Cerúndolo. Anderson returned to professional tennis 14 months later at the 2023 Hall of Fame Open.