2022 Mutua Madrid Open – Men's singles

Carlos Alcaraz defeated defending champion Alexander Zverev in the final, 6–3, 6–1 to win the men's singles tennis title at the 2022 Madrid Open. It was his second Masters 1000 title. Alcaraz was the first man to defeat Rafael Nadal and Novak Djokovic in the same clay court tournament, which he did in the quarterfinals and semifinals, respectively.

Djokovic and Daniil Medvedev were in contention for the world No. 1 singles ranking. Djokovic retained the top ranking by reaching the third round. He became the first player to record at least 30 singles wins at all nine Masters 1000 events.

The semifinal match between Carlos Alcaraz and Novak Djokovic was named by the Association of Tennis Professionals as the ATP Match of the Year.