2022 Prague Open – Doubles
| Doubles | |
|---|---|
| 2022 Prague Open | |
| Champions | Anastasia Potapova Yana Sizikova |
| Runners-up | Angelina Gabueva Anastasia Zakharova |
| Score | 6–3, 6–4 |
| Draw | 16 |
| Seeds | 4 |
Anastasia Potapova and Yana Sizikova defeated Angelina Gabueva and Anastasia Zakharova in the final, 6–3, 6–4 to win the doubles tennis title at the 2022 Prague Open.
Marie Bouzková and Lucie Hradecká were the defending champions, but Bouzková did not participate. Hradecká partnered Andrea Sestini Hlaváčková in the latter's final professional tournament, but lost in the quarterfinals to Miyu Kato and Samantha Murray Sharan.