2022 Prague Open – Singles

Singles
2022 Prague Open
Champion Marie Bouzková
Runner-up Anastasia Potapova
Score6–0, 6–3
Draw32
Seeds8

Marie Bouzková defeated Anastasia Potapova in the final, 6–0, 6–3 to win the singles tennis title at the 2022 Prague Open. It was her maiden WTA Tour title.

Barbora Krejčíková was the defending champion, but lost in the second round to Nao Hibino.

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