2022 San Diego Open – Men's singles

Men's singles
2022 San Diego Open
Champion Brandon Nakashima
Runner-up Marcos Giron
Score6–4, 6–4
Draw28 (4 Q / 3 WC )
Seeds8

Brandon Nakashima defeated Marcos Giron in the final, 6–4, 6–4 to win the singles tennis title at the 2022 San Diego Open. It was his first ATP Tour title, and he won it in his hometown of San Diego.

Casper Ruud was the reigning champion, but competed at the Laver Cup instead.

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