2022 Serbia Open – Singles

Singles
2022 Serbia Open
Champion Andrey Rublev
Runner-up Novak Djokovic
Score6–2, 6–7(4–7), 6–0
Draw28 (4 Q / 3 WC )
Seeds8

Andrey Rublev defeated Novak Djokovic in the final, 6–2, 6–7(4–7), 6–0 to win the singles tennis title at the 2022 Serbia Open.

Matteo Berrettini was the reigning champion, but chose not to defend his title.