2022 Serbia Open – Singles
| Singles | |
|---|---|
| 2022 Serbia Open | |
| Champion | Andrey Rublev |
| Runner-up | Novak Djokovic |
| Score | 6–2, 6–7(4–7), 6–0 |
| Draw | 28 (4 Q / 3 WC ) |
| Seeds | 8 |
Andrey Rublev defeated Novak Djokovic in the final, 6–2, 6–7(4–7), 6–0 to win the singles tennis title at the 2022 Serbia Open.
Matteo Berrettini was the reigning champion, but chose not to defend his title.