2022 US Open – Wheelchair quad singles

Wheelchair quad singles
2022 US Open
Champion Niels Vink
Runner-up Sam Schröder
Score7–5, 6–3

Niels Vink defeated Sam Schröder in the final, 7–5, 6–3 to win the quad singles wheelchair tennis title at the 2022 US Open. It was his first US Open singles title and second major singles title overall.

Dylan Alcott was the reigning champion, but retired from professional wheelchair tennis in January 2022.