2022 US Open – Women's singles

Iga Świątek defeated Ons Jabeur in the final, 6–2, 7–6^(7–5) to win the women's singles tennis title at the 2022 US Open. It was her first US Open title and third major title overall. Świątek was the first player since Angelique Kerber in 2016 to win multiple majors in a season, having also won the 2022 French Open. She became the first Polish woman in the Open Era to reach the US Open quarterfinals and beyond. Świątek was the youngest woman to win three majors since Maria Sharapova in 2008.

Emma Raducanu was the defending champion, but lost in the first round to Alizé Cornet. It was the third time the defending US Open champion lost in the first round, after Svetlana Kuznetsova in 2005 and Kerber in 2017. This marked the second consecutive major where Cornet defeated a reigning major champion (following her victory over Świątek at Wimbledon). Cornet made her 63rd consecutive major appearance, surpassing Ai Sugiyama's all-time record.

This tournament marked the final professional appearance of 23-time singles major champion, Olympic singles gold medalist, and former world No. 1 Serena Williams; she lost to Ajla Tomljanović in the third round. It was the longest match at a major in Williams' career, lasting three hours and five minutes. With her victory over second-ranked Anett Kontaveit in the second round, Williams, at 40 years old, became the oldest player to defeat a top-three opponent on the WTA Tour.

This tournament was also the final major appearance of two-time major champion and former world No. 1 Simona Halep; she lost to Daria Snigur in the first round. Following the tournament, Halep served a provisional suspension for violations of anti-doping rules, which ended in March 2024. She announced her retirement from professional tennis in 2025.

This tournament marked the first time in the Open Era that four Chinese women reached the third round of a major. Elise Mertens had her streak of 18 consecutive major third round appearances broken after losing in the first round to Irina-Camelia Begu.

This was the first edition of the US Open to feature a 10-point tie-break, when the score reaches six games all in the deciding set. Karolína Plíšková defeated Magda Linette in the first round in the first women's singles main-draw 10-point tie-break at the US Open.