2022 WTA Lyon Open – Singles
| Singles | |
|---|---|
| 2022 WTA Lyon Open | |
| Champion | Zhang Shuai |
| Runner-up | Dayana Yastremska |
| Score | 3–6, 6–3, 6–4 |
| Draw | 32 |
| Seeds | 8 |
Zhang Shuai defeated wildcard Dayana Yastremska in the final, 3–6, 6–3, 6–4 to win the Singles title at the 2022 WTA Lyon Open. It was her first title since 2017. Yastremska was participating in her first event since fleeing her native country of Ukraine due to the 2022 Russian invasion of Ukraine.
Clara Tauson was the defending champion, but chose not to participate.