2024 Italian Open – Men's singles

Alexander Zverev defeated Nicolás Jarry in the final, 6–4, 7–5 to win the men's singles tennis title at the 2024 Italian Open. It was his sixth ATP 1000 title and 22nd career title.

Daniil Medvedev was the defending champion, but lost to Tommy Paul in the fourth round.

Hubert Hurkacz became the sixth player born in the 1990s (after Dominic Thiem, Stefanos Tsitsipas, Zverev, Grigor Dimitrov, and Medvedev) to reach at least the quarterfinals at all nine ATP 1000 events. Taylor Fritz became the first American man to reach the quarterfinals of all three clay court Masters events.

Alejandro Tabilo and Jarry became the first Chilean players to reach an ATP 1000 semifinal since Fernando González at the 2009 Italian Open, and marked the first time that multiple Chileans reached the semifinals of the same 1000 event. With his win against Novak Djokovic in the third round, Tabilo also became the second Chilean (after González) to defeat a reigning world No. 1. Djokovic's loss marked the first time that he failed to reach the quarterfinals at this tournament.

This marked the final appearance of former world No. 1 and ten-time champion Rafael Nadal, at an ATP Masters 1000 tournament; he lost in the second round to Hurkacz.