2025 Australian Open – Wheelchair girls' singles

The 2025 Australian Open – Wheelchair Girls' Singles was the inaugural edition of the junior wheelchair tournament at the first Grand Slam of the season. The competition took place at Melbourne Park, Melbourne, Australia, from January 20 to January 26, 2025.

Brazil's Vitória Miranda claimed the title by defeating Great Britain's Hannah Ferguson in the final, with set scores of 6-4, 7-5. With this victory, Miranda became the first champion in the event's history, solidifying her status as one of the top rising stars in junior wheelchair tennis.