2025 Cleveland Open – Singles
| Singles | |
|---|---|
| 2025 Cleveland Open | |
| Champion | Colton Smith |
| Runner-up | Eliot Spizzirri |
| Score | 6–4, 6–7(6–8), 6–3 |
Patrick Kypson was the defending champion but chose not to defend his title.
Colton Smith won the title after defeating Eliot Spizzirri 6–4, 6–7(6–8), 6–3 in the final.