2025 Credit One Charleston Open – Singles
| Singles | |
|---|---|
| 2025 Credit One Charleston Open | |
| Champion | Jessica Pegula |
| Runner-up | Sofia Kenin |
| Score | 6–3, 7–5 |
| Draw | 48 |
| Seeds | 16 |
Jessica Pegula defeated Sofia Kenin 6–3, 7–5 to win the singles tennis title at the 2025 Charleston Open. It was her eighth WTA Tour title, and first on clay.
Danielle Collins was the defending champion, but lost in the quarterfinals to Pegula.