2025 French Open – Wheelchair women's singles

Wheelchair women's singles
2025 French Open
Champion Yui Kamiji
Runner-up Aniek van Koot
Score6–2, 6–2

Yui Kamiji defeated Aniek van Koot in the final, 6–2, 6–2 to win the women's singles wheelchair tennis title at the 2025 French Open. It was her fifth French Open singles title and tenth major singles title overall.

Diede de Groot was the four-time defending champion, but lost in the first round to Li Xiaohui.