2C-B

2C-B
	2C-B structure
	3D representation of a 2C-B molecule
Clinical data
Other names	4-Bromo-2,5-dimethoxyphenethylamine; 2,5-Dimethoxy-4-bromophenethylamine; Nexus; Venus; Bromo; Bees; Erox; Synergy; Performax; Toonies
Routes of; administration	By mouth, insufflation, rectal
Drug class	Serotonergic psychedelic; Hallucinogen; Serotonin 5-HT2A receptor agonist
ATC code	None;
Legal status
Legal status	AU: S9 (Prohibited substance); BR: Class F2 (Prohibited psychotropics); CA: Schedule III; DE: Anlage I (Authorized scientific use only); UK: Class A; US: Schedule I; UN: Psychotropic Schedule II;
Pharmacokinetic data
Metabolism	Liver (MAO and CYP450)
Metabolites	BDMPE, BDMPAA, BDMBA, and others
Onset of action	Oral: 20–90 min
Elimination half-life	1.2–2.5 hours
Duration of action	Oral: 2–8 hours
Excretion	Urine
Identifiers
	IUPAC name 2-(4-Bromo-2,5-dimethoxyphenyl)ethanamine;
CAS Number	66142-81-2;
PubChem CID	98527;
DrugBank	DB01537;
ChemSpider	88978;
UNII	V77772N32H;
KEGG	C22775;
ChEBI	CHEBI:189669;
ChEMBL	ChEMBL292821;
CompTox Dashboard (EPA)	DTXSID10216332 ;
ECHA InfoCard	100.164.088
Chemical and physical data
Formula	C10H14BrNO2
Molar mass	260.131 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COc1cc(CCN)c(OC)cc1Br;
	InChI InChI=1S/C10H14BrNO2/c1-13-9-6-8(11)10(14-2)5-7(9)3-4-12/h5-6H,3-4,12H2,1-2H3; Key:YMHOBZXQZVXHBM-UHFFFAOYSA-N;

2C-B, also known as 4-bromo-2,5-dimethoxyphenethylamine or by the slang name Nexus, is a synthetic psychedelic drug of the 2C family, mainly used as a recreational drug. It was first synthesized by Alexander Shulgin in 1974 for use in psychotherapy.

To date, there is limited scientific information regarding the drug's pharmacokinetics and pharmacological effects in humans. The existing studies primarily classify 2C-B as a stimulant and hallucinogen, and less commonly an entactogen.

2C-B is also known by a number of slang names and appears on the illicit market in multiple forms: as a powder, in capsules or pills. For recreational use, the substance is generally consumed orally or nasally.