4-APBT

4-APBT
Clinical data
Other names4-(2-Aminopropyl)-1-benzothiophene
Drug classSerotonin–norepinephrine–dopamine releasing agent
Identifiers
  • 1-(1-benzothiophen-4-yl)propan-2-amine
Chemical and physical data
FormulaC11H13NS
Molar mass191.29 g·mol−1
3D model (JSmol)
  • CC(Cc1cccc2c1ccs2)N
  • InChI=1S/C11H13NS/c1-8(12)7-9-3-2-4-11-10(9)5-6-13-11/h2-6,8H,7,12H2,1H3
  • Key:NKOJSEHZOSSUEN-UHFFFAOYSA-N

4-APBT, also known as 4-(2-aminopropyl)-1-benzothiophene, is a monoamine releasing agent (MRA) of the amphetamine and benzothiophene families. It acts specifically as a fairly well-balanced serotonin–norepinephrine–dopamine releasing agent (SNDRA), with EC50Tooltip half-maximal effective concentration values of 21.2 nM for serotonin, 46.2 nM for norepinephrine, and 66.6 nM for dopamine in rat brain synaptosomes. 4-APBT was first described in the scientific literature by 2020.

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