4-Aminoquinoline
| Names | |
|---|---|
| Preferred IUPAC name Quinolin-4-amine | |
| Identifiers | |
| 3D model (JSmol) | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.167.771 | 
| PubChem CID | |
| UNII | |
| CompTox Dashboard (EPA) | |
| 
 | |
| 
 | |
| Properties | |
| C9H8N2 | |
| Molar mass | 144.177 g·mol−1 | 
| Appearance | Powder to crystalline, White/Yellow/Orange | 
| Melting point | 151–155 °C (304–311 °F; 424–428 K) | 
| Hazards | |
| Occupational safety and health (OHS/OSH): | |
| Main hazards | Causes skin and serious eye irritation | 
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references | |
4-Aminoquinoline is a form of aminoquinoline with the amino group at the 4-position of the quinoline. The compound has been used as a precursor for the synthesis of its derivatives.
A variety of derivatives of 4-aminoquinoline are antimalarial agents useful in treating erythrocytic plasmodial infections. Examples include amodiaquine, chloroquine, and hydroxychloroquine. Other uses for the derivatives are: anti-asthmatic, antibacterial, anti-fungal, anti-malarial, antiviral and anti-inflammatory agents.
A patent application for 4-aminoquinoline compounds was filed in 2002 and published in 2005.