4-Hydroxyphenylpyruvate dioxygenase
| 4-hydroxyphenylpyruvate dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Homodimer of 4-Hydroxyphenylpyruvate dioxygenase. Red ribbon represents iron-containing catalytic domain (with Fe 2+ represented as red-orange spheres); blue represents the oligomeric domain. Image generated from published structural data | |||||||||
| Identifiers | |||||||||
| EC no. | 1.13.11.27 | ||||||||
| CAS no. | 9029-72-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| 4-hydroxyphenylpyruvate dioxygenase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | HPPD | ||||||
| Alt. symbols | HPD; PPD | ||||||
| NCBI gene | 3242 | ||||||
| HGNC | 5147 | ||||||
| OMIM | 609695 | ||||||
| RefSeq | NM_002150 | ||||||
| UniProt | P32754 | ||||||
| Other data | |||||||
| EC number | 1.13.11.27 | ||||||
| Locus | Chr. 12 q24-qter | ||||||
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4-Hydroxyphenylpyruvate dioxygenase (HPPD), also known as α-ketoisocaproate dioxygenase (KIC dioxygenase), is an Fe(II)-containing non-heme oxygenase that catalyzes the second reaction in the catabolism of tyrosine - the conversion of 4-hydroxyphenylpyruvate into homogentisate. HPPD also catalyzes the conversion of phenylpyruvate to 2-hydroxyphenylacetate and the conversion of α-ketoisocaproate to β-hydroxy β-methylbutyrate. HPPD is an enzyme that is found in nearly all aerobic forms of life.