5-lipoxygenase-activating protein

ALOX5AP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Q7R, 2Q7M
Identifiers
Aliases	ALOX5AP, FLAP, arachidonate 5-lipoxygenase activating protein
External IDs	OMIM: 603700; MGI: 107505; HomoloGene: 1231; GeneCards: ALOX5AP; OMA:ALOX5AP - orthologs
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	149,224,963 bp
RNA expression pattern
	Top expressed in
	blood; ; trabecular bone; ; bone marrow; ; right lung; ; bone marrow cells; ; monocyte; ; upper lobe of left lung; ; spleen; ; lower lobe of lung; ; periodontal fiber;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; tibiofemoral joint; ; blood; ; right lung lobe; ; ankle; ; interventricular septum; ; carotid body; ; spleen; ; sciatic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glutathione transferase activity; protein N-terminus binding; leukotriene-C4 synthase activity; glutathione peroxidase activity; protein binding; arachidonic acid binding; enzyme activator activity;
Cellular component	integral component of membrane; nuclear membrane; endoplasmic reticulum membrane; membrane; nuclear envelope; endoplasmic reticulum; nucleus;
Biological process	cellular response to calcium ion; leukotriene metabolic process; positive regulation of catalytic activity; protein homotrimerization; lipoxygenase pathway; leukotriene biosynthetic process; lipoxin metabolic process; cellular oxidant detoxification; lipoxin biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	241
	11690
	n/a
	ENSMUSG00000060063
	P20292
	P30355
	NM_001204406; NM_001629
	NM_009663; NM_001308462
	NP_001191335; NP_001620
	NP_001295391; NP_033793
	Wikidata
View/Edit Human	View/Edit Mouse

Arachidonate 5-lipoxygenase-activating protein also known as 5-lipoxygenase activating protein, or FLAP, is a protein that in humans is encoded by the ALOX5AP gene.