5-HT1A receptor

HTR1A
Identifiers
Aliases	HTR1A, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled, 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD, 5-hydroxytryptamine receptor 1A
External IDs	OMIM: 109760; MGI: 96273; HomoloGene: 20148; GeneCards: HTR1A; OMA:HTR1A - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	63,962,507 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	105,584,630 bp
RNA expression pattern
	Top expressed in
	entorhinal cortex; ; middle temporal gyrus; ; Brodmann area 46; ; superior vestibular nucleus; ; superior frontal gyrus; ; hippocampus proper; ; prefrontal cortex; ; endothelial cell; ; Brodmann area 23; ; dorsolateral prefrontal cortex;
	Top expressed in
	ventral nuclear group; ; subthalamus; ; ventral nucleus of lateral geniculate body; ; ventral posterolateral nucleus; ; ventral posteromedial nucleus; ; medial habenular nucleus; ; zona incerta; ; lateral habenular nucleus; ; thalamic reticular nucleus; ; ventral lateral nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; G protein-coupled serotonin receptor activity; protein binding; serotonin binding; neurotransmitter receptor activity; receptor-receptor interaction;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; dendrite;
Biological process	G protein-coupled receptor signaling pathway; regulation of behavior; vasoconstriction; adenylate cyclase-inhibiting serotonin receptor signaling pathway; serotonin metabolic process; behavioral fear response; regulation of dopamine metabolic process; regulation of serotonin secretion; exploration behavior; serotonin receptor signaling pathway; positive regulation of cell population proliferation; regulation of hormone secretion; cell population proliferation; signal transduction; animal behavior; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	3350
	15550
	ENSG00000178394
	ENSMUSG00000021721
	P08908
	Q64264
	NM_000524
	NM_008308
	NP_000515
	NP_032334
	Wikidata
View/Edit Human	View/Edit Mouse

The serotonin 1A receptor (or 5-HT_1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin, also known as 5-HT, a neurotransmitter. 5-HT1A is expressed in the brain, spleen, and neonatal kidney. It is a G protein-coupled receptor (GPCR), coupled to the Gi protein, and its activation in the brain mediates hyperpolarization and reduction of firing rate of the postsynaptic neuron. In humans, the serotonin 1A receptor is encoded by the HTR1A gene.