A-349821

A-349821
Identifiers
	IUPAC name [4-[4-[3-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]propoxy]phenyl]phenyl]-morpholin-4-ylmethanone;
CAS Number	372513-99-0 556835-30-4 (trifluoroacetate salt);
PubChem CID	9954017;
IUPHAR/BPS	1217;
ChemSpider	8129627 ;
UNII	67WL275ISI;
ChEMBL	ChEMBL179702 ;
CompTox Dashboard (EPA)	DTXSID701116601 ;
Chemical and physical data
Formula	C26H34N2O3
Molar mass	422.569 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H]1CC[C@H](N1CCCOC2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)N4CCOCC4)C;
	InChI InChI=1S/C26H34N2O3/c1-20-4-5-21(2)28(20)14-3-17-31-25-12-10-23(11-13-25)22-6-8-24(9-7-22)26(29)27-15-18-30-19-16-27/h6-13,20-21H,3-5,14-19H2,1-2H3/t20-,21-/m1/s1 ; Key:CFUHKRLMDNFZED-NHCUHLMSSA-N ;
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A-349,821 is a potent and selective histamine H₃ receptor antagonist (or possibly an inverse agonist). It has nootropic effects in animal studies, although there do not appear to be any plans for clinical development at present and it is currently only used in laboratory research.

Identifiers

IUPAC name [4-[4-[3-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]propoxy]phenyl]phenyl]-morpholin-4-ylmethanone
CAS Number	372513-99-0^N 556835-30-4 (trifluoroacetate salt)
PubChem CID	9954017
IUPHAR/BPS	1217
ChemSpider	8129627^Y
UNII	67WL275ISI
ChEMBL	ChEMBL179702^Y
CompTox Dashboard (EPA)	DTXSID701116601
Chemical and physical data
Formula	C₂₆H₃₄N₂O₃
Molar mass	422.569 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C[C@@H]1CC[C@H](N1CCCOC2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)N4CCOCC4)C
InChI InChI=1S/C26H34N2O3/c1-20-4-5-21(2)28(20)14-3-17-31-25-12-10-23(11-13-25)22-6-8-24(9-7-22)26(29)27-15-18-30-19-16-27/h6-13,20-21H,3-5,14-19H2,1-2H3/t20-,21-/m1/s1^Y Key:CFUHKRLMDNFZED-NHCUHLMSSA-N^Y
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