| A41 | 
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| Maintained by | 
| Length | 155.2 mi (249.8 km) | 
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| Existed | 1922–present | 
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| Southeast end | A40 in Westminster, London | 
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| Major intersections | A1 in Barnet, London 
  M1 near ElstreeM53 near HootonM25 near Abbots Langley
 M40 / A34 near Bicester
 M42 / A4141 near Solihull
 M5 in West Bromwich
 M54 near Tong
 
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| Northwest end | A57 / A59 / A5038 in Liverpool | 
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| Country | United Kingdom | 
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| Counties | Greater London, Hertfordshire, Buckinghamshire, Oxfordshire, West Midlands, Staffordshire, Shropshire, Cheshire, Merseyside | 
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| Primary destinations
 | London West End
 Brent Cross
 Edgware
 Watford
 Hemel Hempstead
 Aylesbury
 Bicester
 Solihull
 Birmingham
 West Bromwich
 Wolverhampton
 Whitchurch
 Chester
 Ellesmere Port
 Birkenhead
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The A41 is a trunk road between London and Birkenhead, England. Now in parts replaced by motorways, it passes through or near Watford, Kings Langley, Hemel Hempstead, Aylesbury, Bicester, Solihull, Birmingham, West Bromwich, Wolverhampton, Newport, Whitchurch, Chester and Ellesmere Port.
With the opening of the M40 extension in 1990 from junction 8, much of the route was downgraded. The sections between Bicester and the M42 near Solihull in the Midlands have been re-classified B4100, A4177 and A4141.